Benefits of Active Mānuka Honey

Health Benefits

• Helps to promote general wellness & overall digestive health
• Reduces oral pathogens in plaque aiding in oral health
• Helps to soothe a sore throat, helps protect against common cold
• Helps to relieve sinus infection when used with nasal rinse
• Helps to relieve mild digestive upsets, indigestion, gastric reflux
• Aids in the healing of stomach ulcers, and irritable bowel syndrome (IBS)
• Promotes acne reduction, enhances facial complexion
• Helps treat external wounds, even those with antibiotic resistant bacteria such as MRSA

Great-Tasting, Natural Food, No Side Effects

Active Mānuka honey is a great alternative to, or compliment to, traditional medications.  It can be enjoyed daily, as part of an overall wellness approach, or taken in response to specific health issues.  

Links To Some Interesting Articles

Science & Medical Research

The pace of scientific research into the wellness and healing properties of Manuka Honey has accelerated in recent years.  We review this information regularly and organize what we think are the best and most useful papers here.

Review of Manuka Honey Research

• Therapeutic Manuka Honey: No Longer So Alternative 

Anti-inflammatory

• Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation

Antioxidant

• Antibacterial effect of Manuka honey on Clostridium difficile

Cancer

• Honey and Cancer: Current Status and Future Directions
• Manuka Honey Induces Apoptosis of Epithelial Cancer Cells through Aquaporin-3 and Calcium Signaling
• Intravenous Administration of Manuka Honey Inhibits Tumor Growth and Improves Host Survival When Used in Combination with Chemotherapy in a Melanoma Mouse Model  
• Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability  
• Effectiveness of Honey on Radiation-Induced Oral Mucositis, Time to Mucositis, Weight Loss, and Treatment Interruptions Among Patients With Head and Neck Malignancies: A Meta-Analysis and Systematic Review of Literature
• Oxidative stress, inflammation, and cancer: How are they linked?   
• Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor   
• The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells  

• Honey and Cancer: Current Status and Future Directions

• Manuka Honey Induces Apoptosis of Epithelial Cancer Cells through Aquaporin-3 and Calcium Signaling

Cystic Fibrosis

• A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey  
• Manuka honey to kill drug-resistant bacteria found in cystic fibrosis infections  

• Anti-pseudomonad Activity of Manuka Honey and Antibiotics in a Specialized ex vivo Model Simulating Cystic Fibrosis Lung Infection  

• Manuka honey versus saline sinus irrigation in the treatment of cystic fibrosis-associated chronic rhinosinusitis: A randomised pilot trial

Gastric Ulcers, H. Pylori

• Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats  
• Molecular Mechanisms of Natural Honey Against H. pylori Infection Via Suppression of NF-κB and AP-1 Activation in Gastric Epithelial Cells  

Gut

• Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats
• The controlled in vitro susceptibility of gastrointestinal pathogens to the antibacterial effect of manuka honey

Immune Support

• Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells.  
  
  

Oral Health

• Effect of Manuka honey, chlorhexidine gluconate and xylitol on the clinical levels of dental plaque.  
• Antibacterial potential of Manuka honey against three oral bacteria in vitro.  
• The Effects of Manuka Honey on Plaque and Gingivitis: A Pilot Study.  

Parasites

• Comparative effect of manuka honey on anaerobic parasitic protozoans with standard drug therapy under in vitro conditions: A preliminary study.  

Pathogens, Bacteria, Viruses

• Antibacterial effect of Manuka honey on Clostridium difficile 
• Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey  
• Comprehensive In Situ Killing of Six Common Wound Pathogens With Manuka Honey Dressings Using a Modified AATCC-TM100  
• The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis
  https://www.anbg.gov.au/leptospermum/leptospermum-scoparium.html

• Manuka-type honeys can eradicate biofilms produced by Staphylococcus aureus strains with different biofilm-forming abilities  
• In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles  
• Proteomic and genomic analysis of methicillin-resistant Staphylococcus aureus (MRSA) exposed to manuka honey in vitro demonstrated down-regulation of virulence markers  
• Identification and Quantification of Methylglyoxal as the Dominant Antibacterial Constituent of Manuka  
• Secondary Bacterial Infections Associated with Influenza Pandemics

Sinusitis

• Manuka honey sinus irrigation for the treatment of chronic rhinosinusitis: a randomized controlled trial  
• The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients 

Wound, Skin Care

• Acceptability to patients of a honey dressing for non-healing venous leg ulcers  
• Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies  
• Resolution of folliculitis decalvans with Medical Honey  
• Manuka honey‐impregnated dressings in the treatment of neuropathic diabetic foot ulcers  
• Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration   

• Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies

Miscellaneous

• In vivo absorption and metabolism of leptosperin and methyl syringate, abundantly present in manuka honey  
• Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand  

News Articles & Medical Reporting

• Story about Tom Lloyd, man who credits Manuka honey with saving his leg from rare infection    
• Discussion about recent research study on use of manuka honey against MRSA & other "superbugs."  
• BBC 2004 "Harnessing Honey's Healing Power."  Dr. Peter Molan  
• PRWEB March 2012 overview of health benefits of manuka honey  
• 5 Benefits Of Manuka Honey In Ulcerative Colitis  

Read on to learn how Manuka honey is made.  Click here.